个人简介

　　高级工程师，新加坡国立大学博士，深圳中山妇产医院临床研究(GCP/IIT)负责人，深圳市海外高层次人才。

　　擅长领域： 多囊卵巢综合征和卵巢低反应的病理机制、子宫内膜免疫微环境的调控机制。

　　学术任职：广东省免疫学会生殖免疫学专业委员会委员，美国生殖免疫协会会员，并担任Frontiers in Immunology, Frontiers in Endocrinology, American Journal of Reproductive Immunology等多家SCI杂志审稿专家。

　　学术成果：

　　一、主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序)：

　　1. 深圳市自然科学基金面上项目，JCYJ20230807150200001，PCOS蜕膜衰老稳态失衡的分子机制，2023/10-2026/10，15万，在研，主持。

　　2. 深圳市自然科学基金面上项目，JCYJ20220530172814032，SIRT1缓解高雄激素诱导的PCOS子宫内膜基质细胞氧化应激的机制研究，2022/10-2025/10，15万, 在研, 参与。

　　3. 国家自然科学基金委员会，青年项目，82001547，孕酮通过调控树突状细胞脂肪酸代谢参与母胎免疫耐受的分子机制，2021/01-2023/12，24万元，结题，主持。

　　4. 深圳市自然科学基金面上项目，JCYJ20190813160809117，孕酮参与母胎界面树突状细胞免疫代谢调控的分子机制，2020/10-2023/09，10万，结题，主持。

　　5. 广东省自然科学基金项目，2019A15150109，孕酮参与母胎界面DC 代谢重塑和功能调控的分子机制，2019/10-2022/09，10万，结题，主持。

　　6. 深圳市卫生和计划生育委员会博士创新项目，SZBC2018003，IDO在复发性流产中的作用及分子机制，2018/05-2021/05,10万，结题，主持。

　　7. 中华医学会临床医学科研专项资金项目，17020300699，子宫内膜树突状细胞影响反复种植失败患者妊娠结局的分子机制研究，2018/01-2019/12，15万，结题，主持。

　　8. 深圳市科技创新委员会基础研究项目，JCYJ20170307140647669，子宫内膜DC通过ILT4/HLA-G通路影响反复种植失败的分子机制研究，2017/05-2020/05，10万，结题，主持。

　　二、代表性研究成果和学术奖励(分类按时间倒序排序)：

　　1. Su Liu, Sainan Zhang, Ling Hong, Lianghui Diao, Songchen Cai, Tailang Yin*, Yong Zeng*. Characterization of progesterone-induced dendritic cells in metabolic and immunologic reprogramming. J Reprod Immunol 2023; 159: 104128.

　　2. Su Liu#, Ling Hong#, Ruochun Lian, Shan Xiao, Yuye Li, Lianghui Diao* and Yong Zeng*. Transcriptomic Analysis Reveals Endometrial Dynamics in Normoweight and Overweight/Obese Polycystic Ovary Syndrome Women. Front. Genet. 2022; 13: 874487.

　　3. Su Liu, Ling Hong, Meilan Mo, Shan Xiao, Xuejin Wang, Xinfeng Fan, Sainan Zhang, Lianghui Diao and Yong Zeng*. Association of antimüllerian hormone with polycystic ovarian syndrome phenotypes and pregnancy outcomes of in vitro fertilization cycles with fresh embryo transfer. BMC Pregnancy and Childbirth 2022; 22(1): 171.

　　4. Jingxuan Wang, Tailang Yin*, Su Liu*. Dysregulation of immune response in PCOS organ system. Front. Immunol. 2023; 14:1169232.

　　5. Sainan Zhang#, Jinli Ding#, Yan Zhang#, Su Liu*, Jing Yang*, Tailang Yin*. Regulation and Function of Chemokines at the Maternal-Fetal Interface. Front Cell Dev Biol 2022; 10: 826053.

　　6. Yan Jia, Ya-Jun Dong, Yu-Lin Sha, Song-Chen Cai, Liang-Hui Diao, Zhu Qiu, Yan-Hua Guo, Yan Huang, Hong-Xia Ye, Su Liu*. Effectiveness comparison between Endometrial Receptivity Array, Immune Profiling and the combination in treating patients with multiple implantation failure. Am J Reprod Immunol 2022; 87(3): e13513.

　　7. Sainan Zhang#, Su Liu#*, Ling Hong, Xiaohui Wang, Lianghui Diao, Songchen Cai, Tailang Yin* and Yong Zeng*. Identification of Profound Metabolic Alterations in Human Dendritic Cells by Progesterone Through Integrated Bioinformatics Analysis. Front. Immunol 2021; 12: 806110.

　　8. Su Liu#, Ling Hong#, Meilan Mo, Shan Xiao, Cong Chen, Yuye Li, Ruochun Lian, Xuejin Wang, Songchen Cai, Lianghui Diao*, Yong Zeng*. Evaluation of endometrial immune status of polycystic ovary syndrome. J Reprod Immunol 2021; 144: 103282.

　　9. Su Liu, Ling Hong, Yuye Li, Ruochun Lian, Xiaohui Wang and Yong Zeng*. Association between endometrial indoleamine 2,3-dioxygenase expression level and pregnancy outcomes in women undergoing first in vitro fertilization treatment. BMC Pregnancy and Childbirth 2021; 21(1): 33.

　　10. Su Liu, Meilan Mo, Shan Xiao, Longfei Li, Xiuyu Hu, Ling Hong, Linlin Wang, Ruochun Lian, Chunyu Huang, Yong Zeng and Lianghui Diao*. Pregnancy Outcomes of Women With Polycystic Ovary Syndrome for the First In Vitro Fertilization Treatment: A Retrospective Cohort Study With 7678 Patients. Front Endocrinol 2020; 11: 575337.

　　11. Su Liu#, Fen Xu#, Hongxia Wei, Chunyu Huang, Xian Chen, Ruochun Lian, Yong Zeng*. The correlation of thyroid autoimmunity and peripheral and uterine immune status in women with recurrent miscarriage. J Reprod Immunol 2020; 139: 103118.

　　12. Ruochun Lian, Xiaohui Wang, Rong Lin, Huimin Zeng, Yong Zeng, Su Liu*. Evaluation of granulocyte colony-stimulating factor on the treatment of thin endometrium during frozen-thawed embryo transfer cycles: a retrospective cohort study. Gynecol Endocrinol 2020; 36(4): 370-374.

　　13. Su Liu#, Hongxia Wei#, Yuye Li, Lianghui Diao, Ruochun Lian, Xu Zhang, Yong Zeng*. Characterization of Dendritic Cell (DC)10 in recurrent miscarriage and recurrent implantation failure. Reproduction 2019; 158(3): 247-255.

　　14. Hongxia Wei#, Su Liu#, Ruochun Lian, Chunyu Huang, Yuye Li, Lanna Chen, Yong Zeng*. Abnormal Expression of Indoleamine 2, 3-Dioxygenase in Human Recurrent Miscarriage. Reprod Sci 2019; 1933719119833788.

　　15. Su Liu, Hongxia Wei, Yuye Li, Chunyu Huang, Ruochun Lian, Jian Xu, Lanna Chen, Yong Zeng*. Downregulation of ILT4+ dendritic cells in recurrent miscarriage and recurrent implantation failure. Am J Reprod Immunol 2018; 80(4): e12998.

　　16. Su Liu, Lianghui Diao, Chunyu Huang, Yuye Li, Yong Zeng*, Joanne Y.H. Kwak-Kim*. The role of decidual immune cells on human pregnancy. J Reprod Immunol 2017; 124: 44-53