黄春宇

姓名:黄春宇

职称/头衔:博士

所属科室:生殖科

从业年限:

技术专业:种植窗期免疫细胞对胚胎的耐受机制、复发性流产和反复种植失败患者的子宫内膜免疫细胞评估体系的建立

个人简介

香港大学博士。锦欣医疗科技创新中心副主任,深圳中山泌尿外 科医院院长助理。
擅长领域:NK细胞及γδ-T细胞在生殖障碍疾病中的作用机制研究 ;医学统计学及人工智能技术(AI)在生殖临床辅助决策中的应 用探索研究。
社会任职:美国生殖免疫协会(ASRM)委员,中国免疫学会会员,广东省免疫协会生殖免 疫专业委员会委员,《Journal of Reproductive Immunology》和 《American Journal of Reproductive Immunology》审稿专家。

学术成果:
主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序):
1、 深圳市卫计委学科建设能力提升项目、SZXJ2018004、子宫内膜自然杀伤细胞对反 复胚胎种植失败患者妊娠结局的预测价值及临床应应用、2018/05-2021/05、10 万、 在研、主持;
2、 中华医学会生殖医学青年医师研究与发展项目、18010110740、HCG 日高水平孕酮 影响子宫 NK 细胞功能的分子机制研究、2019/06-2021/06、13 万、在研、主持;
3、 国自然青年科学基金项目、81701529、HIF-1α 与雌激素协同调控 Tregs 功能和子宫 2 内膜微环境的机制研究、2018/01-2020/12,20 万,在研、参与(第二);
4、 深圳市科创委基础研究计划、JCYJ20150402165325178、uNK 通过毒性颗粒影响 RIF 患者妊娠结局的分子机制研究、2015/08-2017/08、15 万元、已结题、参与(第二);
5、 深圳市科创委基础研究计划、JCYJ20120829150019348、反复胚胎种植失败中树突 状细胞对免疫耐受和血管新生的影响、2013/06-2016/06、20 万元、已结题、参与(第 三)。

代表性研究成果和学术奖励
一、期刊论文

1. 第一作者或通讯作者论文
(1) Chunyu Huang, Yong Zeng, Wenwei Tu* , Single-cell RNA Sequencing Deciphers Immune Landscape of Human Recurrent Miscarriage. Genomics, Proteomics & Bioinformatics, Accept.
(2) Chunyu Huang, Yongnu Zhang, Zheng Xiang, Yuye Li, Rong Lin, Jian Xu, Wenwei Tu, Yong Zeng, Granzyme B-expressing γδ-T and NK cells as a predictor of clinical pregnancy failure in patients with unexplained implantation failure. Journal of Reproductive Immunology. DOI: 10.1016/j.jri.2020.103269.
(3) Yongnu Zhang† , Chunyu Huang† , Ruochun Lian, Jian Xu, Yunfeng Fu, Yong Zeng*, Wenwei Tu*, The low cytotoxic activity of peripheral blood NK cells may relate to unexplained recurrent miscarriage. American Journal of Reproductive Immunology. DOI: 10.1111/aji.13388
(4) Chunyu Huang, Yong Zeng*, Wenwei TU*, The role of gdT cells during human pregnancy. American Journal of Reproductive Immunology. 2017, 78 (2), DOI: 10.1111/aji.12713.
(5) Chunyu Huang† , Hongzhan Zhang† , Xian Chen, Lianghui Diao, Ruochun Lian, Xu Zhang, Lina Hu* , Yong Zeng* . Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case-controlled study. American Journal of Reproductive Immunology. 2016, 76(4), 326-332. (共第一作者) 
(6) Chunyu Huang, Peiyan Liang, Lianghui Diao, Cuicui Liu, Xian Chen, Guangui Li, Cong Chen and Yong Zeng* . Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure. Int. J. Environ. Res. Public Health 2015, 12, 10352-10361.
(7) Jinli Wang# , Chunyu Huang# , Minhao Wu, Qiu Zhong, Kun Yang, Miao Li, Xiaoxia Zhan, Jinsheng Wen, Lin Zhou*, Xi Huang*. MRP8/14 induces autophagy to eliminate intracellular Mycobacterium bovis BCG. J Infect, 2015, 70 (4), 415-426. (共第 一作者)
2. 既非第一作者又非通讯作者论文
(1) Linlin Wang# , Longfei Li# , Chunyu Huang, Lianghui Diao, Ruochun Lian, Yuye Li, Shan Xiao, Xiuyu Hu, Meilan Mo and Yong Zeng. Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment. Fertility and Sterility,2019.
(2) Hongxia Wei, Su Liu, Ruochun Lian, Chunyu Huang, Yuye Li, Lanna Chen, Yong Zeng*. Abnormal expression of indoleamine 2, 3-dioxygenase in human recurrent miscarriage. Reproductive Sciences,2019.
(3) Yuye Li# , Shuyi Yu# , Chunyu Huang, Ruochun Lian, Cong Cheng, Su Liu, Longfei Li, Lianghui Diao, Udo R. Markert, Yong Zeng. Evaluation of Peripheral and Uterine Immune Status of Chronic Endometritis in Recurrent Reproductive Failure Patients. Fertility and sterility,2019
(4) Longfei Li# , Linlin Wang# , Chunyu Huang, Lianghui Diao, Yongnu Zhang, Xu Zhang, Jian Xu, Yong Zeng* . Chronic Hepatitis B Infections Altered Peripheral Immune Response in Women with Reproductive Failure. American journal of reproductive immunology. 2018
(5) Su Liu, Hongxia Wei, Yuye Li, Chunyu Huang, Ruochun Lian, Jian Xu, Lanna Chen, Yong Zeng*. Downregulation of ILT4+ dendritic cells in recurrent miscarriage and 4 recurrent implantation failure. American Journal of Reproductive Immunology. 2018, 80 (4), e12998
(6) Tao Zhang, Chunyu Huang, Yan Du, Ruochun Lian, Meilan Mo, Yong Zeng* and Gil Mor. Successful treatment with intrauterine delivery of dexamethasone for repeated implantation failure. American Journal of Reproductive Immunology. 2017, 78(6), e12766
(7) Su Liu, Lianghui Diao, Chunyu Huang, Yuye Li, Yong Zeng* and Joanne Kwak-Kim. The role of decidual immune cells on human pregnancy. Journal of Reproductive Immunology. 124 (2017) 44-53
(8) Xian Chen, Meilan Mo, Chunyu Huang, Lianghui Diao, Guangui Li, Yuye Li, Aaron Lerner, Yehuda Shoenfeld, Yong Zeng*. Association of serum autoantibodies with pregnancy outcome of patients undergoing first IVF/ICSI treatment: A prospective cohort study. Journal of Reproductive Immunology. 122 (2017) 14-20
(9) Jin-Li Ding# , Lianghui Diao# , Tai-lang Yin, Chunyu Huang, Biao Yin, Cong Chen, YI ZHANG, Jie Li, Yan-Xiang Cheng, Yong Zeng, Jing Yang. Aberrant expressions of endometrial Id3 and CTLA-4 are associated with unexplained repeated implantation failure and recurrent miscarriage. American Journal of Reproductive Immunology. DOI:10.1111/aji.12632.
(10) Liang-Hui Diao, Guan-Gui Li, Yuanchang Zhu, Wenwei Tu, Chunyu Huang, Ruo-Chun Lian, Xian Chen, Yuye Li, Tao Zhang, Yong Huang, Yong Zeng. Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells. American Journal of Reproductive Immunology. 2017, 77(3)
(11) PeiYan Liang, LiangHui Diao, ChunYu Huang, RuoChun Lian, Xian Chen, GuanGui Li, Jin Zhao, YuYe Li, XueBing He, Yong Zeng. The pro-inflammatory and anti-inflammatory cytokine profile in women with recurrent implantation failure. Reproductive BioMedicine Online, 2015, 31(6):823-826 
二、大会报告(大会口头报告)
(1) Chunyu Huang, Reproductive Failure: Immune or autoimmune abnormality from male and female. The 8th Congress of the International Society for Gender Medicine, 2017, Japan. (Invited Speaker) 2017, 9.14-17
(2) Chunyu Huang, The prevalence and associated factors of autoantibodies in reproductive failure. First Interdisciplinary Scientific Conference on Autoimmune and Immunodeficiency Diseases, Moscow, Russian, 08-10 December, 2016.
(3) Chunyu Huang, The prevalence of anti-phospholipid antibodies, anti-thyroid antibodies and anti-nuclear antibodies in patients experiencing infertility, repeated implantation failure and recurrent miscarriage. The 10th International Congress on Autoimmunity, Leipzig, Germany, 06-10 April, 2016.
(4) 黄春宇,NK 细胞数量和功能检测在生殖失败患者中的临床应用,广东省免疫学会生殖免 疫学专业委员会2016年学术年会,中国,广州,2016年12月17-18 日 (5) 黄春宇,周围血树突状细胞与复发性流产的相关性研究:病例对照研究,广东省免疫学会 2016年学术年会,中国,广州,2016年9月10日 (6) 黄春宇,反复种植失败患者DC细胞数量和功能分析,2015年中国生殖免疫学会年会暨2015 年重庆市免疫学会年会,中国,重庆,2015年9月
三、授权专利
(1) 黄春宇; 刁梁辉; 陈现; 李玉叶; 连若纯; 陈聪; 一种用于评估子宫内膜容受性 的试剂盒及其使用方法, 2017-10-31, 中国, ZL 2016 1 0021908. X. (发明专利)


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