李龙飞

姓名:李龙飞

职称/头衔:博士 检验中心副主任

所属科室:检验中心

从业年限:

技术专业:复发性流产及反复种植失败的免疫诊疗新策略

个人简介

  副研究员 ,香港中文大学博士&博士后。深圳中山妇产医院检验中心副主任,创新中心副主任,深圳市海外高层次人才。

  擅长领域:母胎免疫对话机制及妊娠疾病干预策略

  学术任职:中国优生优育精准检验工作委员会委员;广东省免疫学会生殖免疫学专业委员会青委会委员;河南省科学保健学会质谱与功能检验专业委员会委员;深圳市医院协会检验医学分会委员。

  学术成果:主持完成国家自然科学基金1项,主持在研省市级课题3项;发表研究论文35篇;授权发明专利2项,申请发明专利2项。

  一、主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序):

  1. 广东省自然科学基金面上项目,“滋养细胞来源外泌体miR-410-5p调控BCL-G抑制蜕膜基质细胞凋亡的机制研究”,2022.01-2024.12,10万元,负责人,在研;

  2. 广东省自然科学基金面上项目,“IGF-1通过上调子宫基质细胞丙酮酸激酶的表达促进蜕膜化的机制研究”,2019.10-2022.09,10万元,负责人,结题;

  3. 深圳市自然科学基金面上项目,“滋养层细胞与母胎界面巨噬细胞极化的相互作用及机制研究”,2020-2023,20万元,负责人,结题;

  4. 国家自然科学基金,“TCP-2肿瘤靶向肽在结肠组织上特异性靶标的分离鉴定及靶向传输免疫治疗药物的研究”,2017.01-2019.12,17.3万元,负责人,结题;

  二、代表性研究成果和学术奖励(分类按时间倒序排序):

  Yang, J., Li, L.#*, Wang, L., et al. Trophoblast-Derived miR-410-5p Induces M2 Macrophage Polarisation and Mediates Immunotolerance at the Fetal-Maternal Interface by Targeting the STAT1 Signalling Pathway. Journal of Translational Medicine, 2024, 22(1):19.(共同第一作者兼共同通讯作者, Q1, IF7.4)

  Yang, J., Wang, L., Ma, J., Diao, L., Chen, J., Cheng, Y., Yang, J., Li, L. Endometrial proteomic profile of patients with repeated implantation failure. Frontiers in Endocrinology 2023;14. (通讯作者, Q1, IF5.2)

  Li, J., Wang, L., Ding, J., Cheng, Y., Diao, L., Li, L.*, Zhang, Y.*, Yin, T.* Multiomics Studies Investigating Recurrent Pregnancy Loss: An Effective Tool for Mechanism Exploration. Front Immunol 2022;13: 826198. (并列通讯作者,Q1, IF 8.78)

  Wang, L., Deng, Z., Yang, J., Zhao, Y., Zhou, L., Diao, L., Li, L.*, Cheng, Y. Epigenetic and transcriptomic characterization of maternal-fetal interface in patients with recurrent miscarriage via an integrated multi-omics approach. J Reprod Immunol 2022;154: 103754. (通讯作者,Q2, IF 3.99)

  Zhou, L., Wang, L., Geng, Q., Zhang, H., Xu, S., Diao, L., Zeng, Y., Mo, M., Li, L.* Endometriosis is associated with a lowered cumulative live birth rate: A retrospective matched cohort study including 3071 in vitro fertilization cycles. J Reprod Immunol 2022;151: 103631. (通讯作者,Q2, IF 3.99)

  Li, L.F., Yue, G.G., Chan, B.C., Zeng, Q., Han, Q.B., Leung, P.C., Fung, K.P., Liu, J.K., Lau, C.B. Rubinoboletus ballouii polysaccharides exhibited immunostimulatory activities through toll-like receptor-4 via NF-kappaB pathway. Phytother Res 2021;35: 2108-2118. (第一作者,Q1, IF 6.38)

  Wang, L., Li, L.#, Li, Y., Huang, C., Lian, R., Wu, T., Ma, J., Zhang, Y., Cheng, Y., Diao, L., Zeng, Y. A History of Endometriosis Is Associated With Decreased Peripheral NK Cytotoxicity and Increased Infiltration of Uterine CD68+ Macrophages. Frontiers in Immunology 2021;12. (并列第一作者,Q1, IF 8.78)

  Li, L., Wang, L., Huang, C., Diao, L., Zhang, Y., Zhang, X., Xu, J., Zeng, Y. Chronic hepatitis B infection alters peripheral immune response in women with reproductive failure. Am J Reprod Immunol 2019;81: e13083. (第一作者,Q2, IF 3.77)

  Wang, L., Li, L.,# Huang, C., Diao, L., Lian, R., Li, Y., Xiao, S., Hu, X., Mo, M., Zeng, Y. Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment. Fertil Steril 2019;112: 250-257 e251. (并列第一作者,Q1, IF 7.49)

  Zeng Q, Li L, Siu W, Jin Y, Cao M, Li W, Chen J, Cong W, Ma M, Chen K, Wu Z. A combined molecular biology and network pharmacology approach to investigate the multi-target mechanisms of Chaihu Shugan San on Alzheimer's disease. Biomed Pharmacother. 2019;120:109370.

  Zeng Q, Li L, Jin Y, Chen Z, Duan L, Cao M, Ma M, Wu Z. A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Paeonia lactiflora Pall. On the Treatment of Alzheimer's Disease. Evid Based Complement Alternat Med. 2019;2019:8706589.

  Li Y, Yu S, Huang C, Lian R, Chen C, Liu S, Li L, Diao L, Markert UR, Zeng Y. Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure. Fertil Steril. S0015-0282(19)32314-3.

  Li, M.X., Li, L.F., Zhang, L., Xiao, Z.G., Shen, J., Hu, W. & Cho, C.H. (2016). Vitamin D and cancer stem cells in the gastrointestinal tract. Curr. Med. Chem. 2017;24(9):918-927. (invited).

  Li, L.F.*(第一作者和通讯作者), Chan, R.L., Lu, L., Shen, J., Zhang, L., Wu, W.K., et al., Cigarette smoking and gastrointestinal diseases: The causal relationship and underlying molecular mechanisms, International Journal of Molecular Medicine. 34 (2014), 372-80.

  Li, L.F.(第一作者), Chan, B.C., Yue, G.G., Lau, C.B., Han, Q.B., Leung, P.C., et al., Two immunosuppressive compounds from the mushroom Rubinoboletus ballouii using human peripheral blood mononuclear cells by bioactivity-guided fractionation, Phytomedicine. 20 (2013), 1196-202.

  Li, M.X., Li, L.F., Zhang, L., Hu, W., Shen, J., Xiao, Z.G., Chan, F.L., Cho, C.H. (2017). 1,25-Dihydroxyvitamin D3 suppresses cancer growth through VDR and mutant p53 in the induction of p21 expression in gastric cancer. Life Sciences 179 (2017) 88–97.

  Wong CC, Zhang L, Wu WK, Shen J, Chan RL, Lu L, Hu W, Li MX, Li LF, Ren SX, Li YF, Li J, Cho CH. Cathelicidin-encoding Lactococcus lactis promotes mucosal repair in murine experimental colitis. J Gastroenterol Hepatol. 2017;32(3):609-619.

  Zeng Q, Ko CH, Siu WS, Li LF, Han XQ, Yang L, Bik-San Lau C, Hu JM, Leung PC. Polysaccharides of Dendrobium officinale Kimura & Migo protect gastric mucosal cell against oxidative damage-induced apoptosis in vitro and in vivo. J Ethnopharmacol. 2017 Jul 4;208:214-224.

  Shen J, Li ZJ, Li LF, Lu L, Xiao ZG, Wu WK, Zhang L, Li MX, Hu W, Chan KM, Cho CH. (2016). Vascular-targeted TNFα and IFNγ inhibit orthotopic colorectal tumor growth. J. Translat. Med. 2016 24;14(1):187.

  Xiao ZG, Shen J, Zhang L, Li LF, Li MX, Hu W, Li ZJ, Cho CH. The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) in Cancers: Current Progress and Future Perspectives. Curr Med Chem. 2016;23(32):3687-3696.

  Shen J, Li WX, Xiao ZG, Zhang L, Li MX, Li LF, Hu W, Lu L, Boudreau F, Cho CH. The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. Curr Med Chem. 2016; 23(11):1131-8.

  Wang L, Hu T, Shen J, Zhang L, Li LF, Chan RL, Li MX, Wu WKK, Cho CH. (2016). Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. Life Sci, pii: S0024-3205(16)30134-5.

  Xu Z, Shen J, Wang MH, Yi T, Yu Y, Zhu Y, Chen B, Chen J, Li L, Li M, Zuo J, Jiang H, Zhou D, Luan J, Xiao Z. Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer. Oncoimmunology. 2016 Jul 11;5(8):e1207841.

  L. Lu, Z.J. Li, L.F. Li, W.K. Wu, J. Shen, L. Zhang, R.L. Chan, L. Yu, Y.W. Liu, S.X. Ren, K.M. Chan, C.H. Cho, Vascular-targeted TNFalpha improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer, J Control Release, 210 (2015) 134-46.

  Chan, B.C.L., Li, L.F., Hu, S.Q., Wat, E., Wong, E.C.W., et al. Gallic Acid Is the Major Active Component of Cortex Moutan in Inhibiting Immune Maturation of Human Monocyte-Derived Dendritic Cells. Molecules. 20 (2015), 16388-403.

  Hu, T., Li, L.F. & Cho, C.H. Chronic inflammation and colorectal cancer: the role of vascular endothelial growth factor. Curr. Pharmaceut. Design. 21 (2015), 2960-7.

  Luo KW, Yue GG, Ko CH, Lee JK, Gao S, Li LF, Li G, Fung KP, Leung PC, Lau CB, In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma. Phytomedicine. 21 (2014), 1078-87.

  二、专利

  1. 吴彤华、李龙飞、宋明哲、叶丽君、陈春媚、曾勇, 一种piRNA及用于检测和/或预测男性生殖功能障碍的试剂盒. 202010230867.1,中国发明专利,2021授权;

  2. 曹之宪、李志杰、李龙飞、李明星, 肿瘤血管及M型巨噬细胞靶向肽及其用途. 201711396421.0,中国发明专利,2021授权;

  3. 李龙飞、王琳琳、张海霞、刁梁辉、蔡松辰,与子宫内膜容受性相关的巨噬细胞标志物及其应用. 202211515257.1,中国发明专利,2022 申请;

  4. 李龙飞、杨静、陈娇、王琳琳、刁梁辉、杨菁,与妊娠风险评估有关的miRNA标志物及其应用. 202211610529.6, 中国发明专利,2022 申请。

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